Synthesis of Glucose-6-phosphate
نویسندگان
چکیده
منابع مشابه
The synthesis of glucose-6-phosphate and 6-phosphogluconate.
In studies of the enzymatic oxidation of 6-phosphogluconate, relatively large quantities of this substance in high purity were required. This led to a search for a convenient preparation of glucoseB-phosphate. Available methods for the synthesis of glucose-6-phosphate, reviewed by Lardy et al. (1, 2), are laborious and not well suited to the preparation of large quantities of this substance. A ...
متن کاملGlucose-6-Phosphate Dehydrogenase
Description Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is the most common human enzyme deficiency that mainly affects the red blood cells (RBCs). A defect in G6PD enzyme leads to the destruction of premature RBCs causing hemolytic anemia because the body can not compensate the destroyed RBCs. Thus, the affected individuals show jaundice (paleness, yellowing of the skin and whites of th...
متن کامل[glucose-6-phosphate Dehydrogenase Deficiency].
LABORATORY DATA biochemical markers metabolic defect chromosomal assignment chromosome X localization chromosome Xq localization chromosome Xq28 localization gene, structural-functional anomalies G6PD (G6PD1) glucose-6-phosphate dehydrogenase, gene chr.Xq28 gene analysis-DNA analysis myelo-erythropoietic disorders glucose-6-phosphate dehydrogenase deficiency haemolytic anaemia isolated hematopo...
متن کاملDehydrogenation of the phosphonate analogue of glucose 6-phosphate by glucose 6-phosphate dehydrogenase.
6,7 -Dideoxy-alpha-D-gluco-heptose 7-phosphonic acid, the isosteric phosphonate analogue of glucose 6-phosphate, was synthesized in six steps from the readily available precursor benzyl 4,6-O-benzylidene-alpha-D-glucopyranoside. The analogue is a substrate for yeast glucose 6-phosphate dehydrogenase, showing Michaelis-Menten kinetics at pH7.5 and 8.0. At both pH values the Km values of the anal...
متن کاملGlucose-6-phosphate dehydrogenase deficiency.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect, being present in more than 400 million people worldwide. The global distribution of this disorder is remarkably similar to that of malaria, lending support to the so-called malaria protection hypothesis. G6PD deficiency is an X-linked, hereditary genetic defect due to mutations in the G6PD gene, which ca...
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ژورنال
عنوان ژورنال: Journal of the agricultural chemical society of Japan
سال: 1956
ISSN: 0002-1407,1883-6844
DOI: 10.1271/nogeikagaku1924.30.59